Dimethyl Sulfoxide → 2-{[4-(methylsulfonyl)benzyl]oxy}-1H-isoindole-1,3(2H)-dione

HRID 450755ノート

反応式

HRID 450755 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH3:12])(=[O:11])=[O:10])=[CH:5][CH:4]=1.CS(C)=O.[OH:17][N:18]1[C:22](=[O:23])[C:21]2=[CH:24][CH:25]=[CH:26][CH:27]=[C:20]2[C:19]1=[O:28].C(=O)([O-])[O-].[K+].[K+]>O>[CH3:12][S:9]([C:6]1[CH:7]=[CH:8][C:3]([CH2:2][O:17][N:18]2[C:22](=[O:23])[C:21]3[C:20](=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:19]2=[O:28])=[CH:4][CH:5]=1)(=[O:11])=[O:10]

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 10665N-HydroxyphthalimideHCID 11430Potassium CarbonateHCID 1235301-(Chloromethyl)-4-methanesulfonylbenzene

生成物 1

HCID 594792692-{[4-(methylsulfonyl)benzyl]oxy}-1H-isoindole-1,3(2H)-dione収率 64.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

To a mixture of 659 mg of 1-(chloromethyl)-4-(methylsulfonyl)benzene and 10 ml of DMSO were added 525 mg of N-hydroxyphthalimide and 445 mg of potassium carbonate, followed by stirring at 50° C. for 2 hours. The reaction solution was cooled, water was then added thereto, and the precipitated crystal was collected by filtration to obtain 685 mg of 2-{[4-(methylsulfonyl)benzyl]oxy}-1H-isoindole-1,3(2H)-dione as a white solid.

後処理

  1. temperatureThe reaction solution was cooled
  2. filtrationthe precipitated crystal was collected by filtration

出典と根拠

ORDレコード
ord-3b50be10981d4f3082d19f516d862428
出典データセット
uspto-grants-2013_07
特許番号
US08486970B2

反応ノート

読み込み中…