Potassium Carbonate → omega-(2-Cyano-4-chlorophenoxy)-2-benzyloxy-acetophenone

HRID 450838ノート

反応式

HRID 450838 の反応式
C(=O)([O-])[O-].[K+].[K+].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([C:15]#[N:16])[CH:9]=1.Br[CH:18]([O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:20]>CN(C=O)C>[C:15]([C:10]1[CH:9]=[C:8]([Cl:7])[CH:13]=[CH:12][C:11]=1[O:14][CH:18]([O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:20])#[N:16]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 27774205-Chloro-2-hydroxybenzonitrileHCID 20153830omega-Bromo-2-benzyloxy-acetophenone

生成物 1

HCID 68535637omega-(2-Cyano-4-chlorophenoxy)-2-benzyloxy-acetophenone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A suspension of potassium carbonate (0.06 g, 4.0 mmol), 4-chloro-2-cyanophenol (0.25 g, 1.6 mmol) and ω-bromo-2-benzyloxy-acetophenone (0.49 g, 1.6 mmol) in dry DMF (10 ml) is stirred at room temperature for 20 h. After evaporating the solvent under reduced pressure the residue is taken up in ethyl acetate. The solution is washed with water, dried over sodium sulfate and evaporated under reduced pressure. The residue is purified by silical gel column chromatography to yield the title compound.

後処理

  1. customAfter evaporating the solvent under reduced pressure the residue
  2. washThe solution is washed with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated under reduced pressure
  5. customThe residue is purified by silical gel column chromatography

出典と根拠

ORDレコード
ord-d607c6706b354f9e9d4543951294f806
出典データセット
uspto-grants-2013_07
特許番号
US08486996B2

反応ノート

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