4-Chloropyridine → HCID 69284462、化合物

HRID 450852

反応式

HRID 450852 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]([O:12]CC)=O)=[CH:7][C:6]=2[CH:15]=1.Cl[C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1>C1COCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10](=[O:12])[C:22]3[CH:17]=[CH:3][CH:2]=[CH:15][C:21]=3[N:20]3[CH2:7][CH2:8][O:9][CH2:18][CH2:19]3)=[CH:7][C:6]=2[CH:15]=1

参加物

4

反応物 2

HCID 122884-ChloropyridineHCID 2799299Ethyl 5-chlorobenzofuran-2-carboxylate

生成物 1

HCID 69284462HCID 69284462、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of ethyl 5-chlorobenzofuran-2-carboxylate (350 mg, 1.56 mmol) in THF (10 ml) is added at −70° C. to a THF solution of lithiated 4-chloropyridine (1.8 mmol prepared according to G. Quéguiner et al., Synthesis 1986, 886-891). The mixture is allowed to reach room temperature within 16 hours before quenching with acetic acid. The product is extracted with chloroform. Drying and chromatography on silicagel gives the title compound.

後処理

  1. custombefore quenching with acetic acid
  2. extractionThe product is extracted with chloroform
  3. customDrying

出典と根拠

ORDレコード
ord-87f9061cd16240e8b1cc4d37ba8988e8
出典データセット
uspto-grants-2013_07
特許番号
US08486996B2

関連ノート

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