Triethylamine → (2-Isocyanatocyclopropyl)benzene

HRID 450966

反応式

HRID 450966 の反応式
[C:1]1([CH:7]2[CH2:9][CH:8]2C(O)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([N:15]([CH2:18]C)CC)C.C1C=CC(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:27])=CC=1>C1(C)C=CC=CC=1>[N:15]([CH:8]1[CH2:9][CH:7]1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[C:18]=[O:27]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 703232-Phenylcyclopropane-1-carboxylic acidHCID 199401P,P-Diphenylphosphinic azide

生成物 1

HCID 582709(2-Isocyanatocyclopropyl)benzene収率 81.5%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 2-phenylcyclopropanecarboxylic acid (1.0 g, 6.17 mmol) in dry toluene (20 mL) was added triethylamine (934 mg, 9.26 mmol) and DPPA (2.0 g, 7.41 mmol) under N2, and the reaction mixture was refluxed for 3 h. The solution was concentrated to give (2-isocyanatocyclopropyl)benzene (800 mg), which was used for the next step without further purification.

後処理

  1. temperaturethe reaction mixture was refluxed for 3 h
  2. concentrationThe solution was concentrated

出典と根拠

ORDレコード
ord-7019917bd13d4f64a7fdaed93ff7742c
出典データセット
uspto-grants-2013_07
特許番号
US08487094B2

関連ノート

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