1-Cyclopropyl-2-methoxyethan-1-amine → 2-chloro-N-(1-cyclopropyl-2-methoxyethyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
反応式
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[C:6]=2[N:7]=1.[CH:19]1([CH:22]([NH2:26])[CH2:23][O:24][CH3:25])[CH2:21][CH2:20]1>>[Cl:1][C:2]1[N:3]=[C:4]([NH:26][CH:22]([CH:19]2[CH2:21][CH2:20]2)[CH2:23][O:24][CH3:25])[C:5]2[CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[C:6]=2[N:7]=1参加物
3
実験手順
2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine (Preparation H) was reacted as described in Preparation Hr with 1-cyclopropyl-2-methoxyethanamine to afford 2-chloro-N-(1-cyclopropyl-2-methoxyethyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine (Preparation Hw) as a mixture of 4 diasteriomers. LC-MS (M+H)+=362.1.
出典と根拠
- ORDレコード
- ord-8872f183153b444c82638386a5199f8b
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486952B2
反応ノート
読み込み中…