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1-Heptyne → N-(2-Hept-1ynyl-phenyl)-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Heptyne | HCID 12350 | — |
| 反応物 | N-Acetyl-O-p-toluenesulfonyl-2-aminophenol | HCID 572553 | — |
| 溶媒 | Ethylacetate heptane | HCID 21899848 | — |
| 生成物 | N-(2-Hept-1ynyl-phenyl)-acetamide | HCID 25221491 | — |
反応手順
This product was prepared from toluene-4-sulfonic acid 2-acetylamino-phenyl ester and 1-heptyne following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane/EtOAc 8:2; yield (92 mg, 80%); 1H NMR δ (CDCl3): 8.47 (d, J=8.51 Hz, 1H), 7.93 (br s, 1H), 7.36 (dm, 1H), 7.31-7.23 (m, 1H), 7.02 (t, J=7.22 Hz, 1H), 2.53 (t, J=7.08 Hz, 2H), 2.21 (s, 3H), 1.63 (p, J=7.11 Hz, 2H), 1.48-1.3 (m, 4H), 0.92 (t, J=7.2 Hz, 3H); LCMS m/z: 229.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08487109B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-7fd335d18fb142e68d695073438d98ff |
| 出典メモ | uspto-grants-2013_07 |