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HRID 451254作成日：2026年10月27日

N-Acetyl-O-p-toluenesulfonyl-2-aminophenol → N-(2-Thiophen-3-ylethynyl-phenyl)-acetamide

https://huagongshe.com/reaction/451254

反応式

関与物質

役割名称HCID仕込み量
反応物N-Acetyl-O-p-toluenesulfonyl-2-aminophenolHCID 572553—
反応物3-EthynylthiopheneHCID 3548422—
溶媒Ethylacetate heptaneHCID 21899848—
生成物N-(2-Thiophen-3-ylethynyl-phenyl)-acetamideHCID 25221493—

反応手順

This product was prepared from toluene-4-sulfonic acid 2-acetylamino-phenyl ester and 3-ethynyl-thiophene following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane/EtOAc 9:1; yield (48 mg, 40%); 1H NMR δ (CDCl3): 8.39 (d, J=8.51 Hz, 1H), 7.9 (br s, 1H), 7.36-7.30 (m, 2H), 7.30-7.21 (m, 3H), 7.02 (t, J=7.24 Hz, 1H), 2.21 (s, 3H); LCMS m/z: 241.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08487109B2
出典データセットuspto-grants-2013_07
ORD IDord-e81ffd3216d941518372ff06814d8435
出典メモuspto-grants-2013_07