反応式
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1OS(C1C=CC(C)=CC=1)(=O)=O)(=[O:3])[CH3:2].[CH2:22]([N:24]([CH2:28][CH3:29])[CH2:25][C:26]#[CH:27])[CH3:23]>CCCCCCC.CCOC(C)=O>[CH2:22]([N:24]([CH2:28][CH3:29])[CH2:25][C:26]#[C:27][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[NH:4][C:1](=[O:3])[CH3:2])[CH3:23]参加物
4
実験手順
This product was prepared from toluene-4-sulfonic acid 2-acetylamino-phenyl ester and diethyl-prop-2-ynyl-amine following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane/EtOAc 8:2; yield (73 mg, 60%); 1H NMR δ (CDCl3): 8.47 (d, J=8.52 Hz, 1H), 7.93 (br s, 1H), 7.36 (dm, 1H), 7.31-7.23 (m, 1H), 7.02 (t, J=7.24 Hz, 1H), 3.54 (s, 2H), 2.62 (q, J=7.13 Hz, 4H), 2.21 (s, 3H), 1.11 (t, J=7.11 Hz, 6H); LCMS m/z: 244.
後処理
- customyield (73 mg, 60%)
出典と根拠
- ORDレコード
- ord-458e3fdf74bd4706859f120a7bb7002b
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08487109B2
関連ノート
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