化工社化工社 化学情報印刷レポート · 研究参考用
5-Phenyl-1-pentyne → 1-(5-Phenyl-pent-1-ynyl)-3-trifluoromethyl-benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Phenyl-1-pentyne | HCID 74573 | — |
| 反応物 | 1-(Tosyloxy)-3-(trifluoromethyl)benzene | HCID 11243986 | — |
| 溶媒 | Heptane | HCID 8900 | — |
| 生成物 | 1-(5-Phenyl-pent-1-ynyl)-3-trifluoromethyl-benzene | HCID 25221609 | — |
反応手順
This product was prepared from toluene-4-sulfonic acid 3-trifluoromethyl-phenyl ester and pent-4-ynyl-benzene following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane; yield (140 mg, 97%); 1H NMR δ (CDCl3): 7.66 (s, 1H), 7.61-7.7.49 (m, 2H), 7.46-7.36 (m, 1H), 7.35-7.16 (m, 5H), 2.79 (t, J=7.15 Hz, 2H), 2.43 (t, J=7.20 Hz, 2H), 1.93 (p, J=7.11 Hz, 2H); LCMS m/z: 288.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08487109B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-d565f91a5ef44e25ae2698ce2bedb337 |
| 出典メモ | uspto-grants-2013_07 |