化工社化工社 化学情報印刷レポート · 研究参考用
1-Ethynylcyclohexene → 1-Cyclohex-1-enylethynyl-3-trifluoromethyl-benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Ethynylcyclohexene | HCID 79128 | — |
| 反応物 | 1-(Tosyloxy)-3-(trifluoromethyl)benzene | HCID 11243986 | — |
| 溶媒 | Heptane | HCID 8900 | — |
| 生成物 | 1-Cyclohex-1-enylethynyl-3-trifluoromethyl-benzene | HCID 11402444 | — |
反応手順
This product was prepared from toluene-4-sulfonic acid 3-trifluoromethyl-phenyl ester and 1-ethynyl-cyclohexene following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane; yield (106 mg, 85%); 1H NMR δ (CDCl3): 7.68 (s, 1H), 7.6-7.7.49 (m, 2H), 7.46-7.37 (m, 1H), 6.28 (m, 1H), 2.31-2.12 (m, 4H), 1.73-1.57 (m, 4H); LCMS m/z: 250.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08487109B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-21e22cb1250f455d80a40c26aef66b6b |
| 出典メモ | uspto-grants-2013_07 |