1-Heptyne → 4-Hept-1-ynyl-benzaldehyde

HRID 451266

反応式

HRID 451266 の反応式
[CH:1]([C:3]1[CH:8]=[CH:7][C:6](OS(C2C=CC(C)=CC=2)(=O)=O)=[CH:5][CH:4]=1)=[O:2].[CH:20]#[C:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>CCCCCCC.CCOC(C)=O>[C:20]([C:6]1[CH:5]=[CH:4][C:3]([CH:1]=[O:2])=[CH:8][CH:7]=1)#[C:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

参加物

4

反応物 2

HCID 123501-HeptyneHCID 51250864-(((4-Methylphenyl)sulfonyl)oxy)benzaldehyde

生成物 1

HCID 252216124-Hept-1-ynyl-benzaldehyde

試薬・触媒・溶媒 1

HCID 21899848Ethylacetate heptane溶媒

実験手順

This product was prepared from toluene-4-sulfonic acid 4-formyl-phenyl ester and 1-heptyne following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane/EtOAc 9:1; yield (60 mg, 70%); 1H NMR δ (CDCl3): 10.02 (s, 1H), 7.8 (d, J=8.65 Hz, 2H), 7.53 (d, J=8.62 Hz, 2H), 2.45 (t, J=7.22 Hz, 2H), 1.62 (p, J=7.11 Hz, 2H), 1.48-1.3 (m, 4H), 0.93 (t, J=7.20 Hz, 3H); LCMS m/z: 200

後処理

  1. customyield (60 mg, 70%)

出典と根拠

ORDレコード
ord-742cc869eb344db2b9fc101f1923d35a
出典データセット
uspto-grants-2013_07
特許番号
US08487109B2

関連ノート

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