1-Ethynylcyclohexene → 4-Cyclohex-1-enylethynyl-benzaldehyde

HRID 451267ノート

反応式

HRID 451267 の反応式
[CH:1]([C:3]1[CH:8]=[CH:7][C:6](OS(C2C=CC(C)=CC=2)(=O)=O)=[CH:5][CH:4]=1)=[O:2].[C:20]([C:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH:23]=1)#[CH:21]>CCCCCCC.C(Cl)Cl>[C:22]1([C:20]#[C:21][C:6]2[CH:5]=[CH:4][C:3]([CH:1]=[O:2])=[CH:8][CH:7]=2)[CH2:27][CH2:26][CH2:25][CH2:24][CH:23]=1

参加物

4

反応物 2

HCID 791281-EthynylcyclohexeneHCID 51250864-(((4-Methylphenyl)sulfonyl)oxy)benzaldehyde

生成物 1

HCID 252216134-Cyclohex-1-enylethynyl-benzaldehyde

試薬・触媒・溶媒 1

HCID 21907733Dichloromethane heptane溶媒

実験手順

This product was prepared from toluene-4-sulfonic acid 4-formyl-phenyl ester and 1-ethynyl-cyclohexene following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane/DCM 1:1; yield (71 mg, 68%); 1H NMR δ (CDCl3): 9.99 (s, 1H), 8.02 (d, J=8.51 Hz, 2H), 7.52 (d, J=8.60 Hz, 2H), 6.31-6.27 (m, 1H), 2.14-2.22 (m, 4H), 1.58-1.73 (m, 4H); LCMS m/z: 210.

後処理

  1. customyield (71 mg, 68%)

出典と根拠

ORDレコード
ord-160872d07e834ee496b7f5f4013d03b5
出典データセット
uspto-grants-2013_07
特許番号
US08487109B2

反応ノート

読み込み中…