Hydrochloric Acid → 1-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-amine dihydrochloride
反応式
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:18][N:17]=[C:16]([CH3:19])[N:15]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:21]>C(Cl)Cl.C(OCC)C>[ClH:21].[ClH:21].[CH3:19][C:16]1[N:15]=[C:14]([N:11]2[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]2)[S:18][N:17]=1参加物
5
実験手順
To a solution of [1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-carbamic acid tert-butyl ester (256 mg, 0.86 mmol) in CH2Cl2 (8.6 mL) was added at room temperature under stirring a 2 M HCl solution in diethyl ether (4.3 mL) and was stirred at room temperature over night. The solvent was removed under reduced pressure. The crude product was treated twice with diethyl ether to yield the title compound as a yellow semi-solid (260 mg, 100%)
後処理
- customThe solvent was removed under reduced pressure
- additionThe crude product was treated twice with diethyl ether
出典と根拠
- ORDレコード
- ord-28a4ee56b1b94e49b67e9637b13d473e
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486967B2
反応ノート
読み込み中…