Hydrochloric Acid → HCID 67342484、化合物

HRID 451486ノート

反応式

HRID 451486 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:25]2[CH:26]=[C:27]([CH:37]=[CH:38][CH:39]=2)[CH2:28][NH:29]C(=O)OC(C)(C)C)[C:5]2[N:6]([N:8]=[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][N:15]([C:18]4[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20][N:19]=4)[CH2:14][CH2:13]3)[N:10]=2)[CH:7]=1.[ClH:40]>C(Cl)Cl.CCOCC>[ClH:40].[ClH:40].[NH2:29][CH2:28][C:27]1[CH:26]=[C:25]([C:4]2[C:5]3[N:6]([N:8]=[C:9]([NH:11][CH:12]4[CH2:13][CH2:14][N:15]([C:18]5[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20][N:19]=5)[CH2:16][CH2:17]4)[N:10]=3)[CH:7]=[C:2]([CH3:1])[CH:3]=2)[CH:39]=[CH:38][CH:37]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 67343427HCID 67343427、化合物

生成物 1

HCID 67342484HCID 67342484、化合物収率 89%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl 3-(6-methyl-2-(1-(6-methylpyrimidin-4-yl)piperidin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzylcarbamate (46 mg, 87.0 μmol) in methylene chloride (1 mL) was added 2 M solution of HCl in Ether (500 μL). The suspension was stirred at room temperature over night. The solvent was decanted and the residue was digerated with diethyl ether three times. The title compound was dried under reduced pressure and was obtained as a yellow solid (39 mg, 89%). MS ISP (m/e): 429.3 (100) [(M+H)+], 412.4 (57).

後処理

  1. customThe solvent was decanted
  2. dry with materialThe title compound was dried under reduced pressure

出典と根拠

ORDレコード
ord-0738f7ef6465464898f6e2c1113b67ed
出典データセット
uspto-grants-2013_07
特許番号
US08486967B2

反応ノート

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