化工社化工社 化学情報印刷レポート · 研究参考用
Water → 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2,5-Hexanedione | HCID 8035 | — |
| 反応物 | 1-Methyl-3-aminopyrazole | HCID 137254 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole | HCID 13248995 | — |
反応手順
To a solution of 1-methyl-1H-pyrazol-3-amine (9.5 g, 98 mmol) and acetonylacetone (11.2 g, 98 mmol) in toluene (150 mL), AcOH (1.5 mL) is added, heated to reflux with a water separator until the formation of water ceased. Concentrated to dry. The residue is purified by flash column to give product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541432B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-0937fb3db8924a38996162cfa19c76bf |
| 出典メモ | uspto-grants-2013_09 |