Hydrochloric Acid → 1-(2-Chloropyridin-4-yl)piperidin-4-amine dihydrochloride
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([NH:14]C(=O)OC(C)(C)C)[CH2:10][CH2:9]2)[CH:5]=[CH:4][N:3]=1.[ClH:22]>ClCCl>[ClH:1].[ClH:22].[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([NH2:14])[CH2:10][CH2:9]2)[CH:5]=[CH:4][N:3]=1参加物
4
実験手順
To a solution of tert-butyl 1-(2-chloropyridin-4-yl)piperidin-4-ylcarbamate (1.00 g, 3.21 mmol) in dichloromethane (16 mL) was added HCl (2 M in diethylether, 8.02 mL, 16.0 mmol) and the reaction mixture was stirred at room temperature over night for 18 hours. The mixture was then filtered off and the white precipitate washed with dichloromethane and diethylether and dried to afford the title compound (913 mg, 99%) as a white solid. MS ISP (m/e): 212.1/214.1 [(M+H)+].
後処理
- filtrationThe mixture was then filtered off
- washthe white precipitate washed with dichloromethane and diethylether
- customdried
出典と根拠
- ORDレコード
- ord-0ee34b7580454f07942e541b9b7384c2
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486967B2
反応ノート
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