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Dichloromethane → 3-(4-Trifluoromethyl-cyclohex-1-enyl)-pyridin-2-ylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | 2-(Pivaloylamino)pyridine | HCID 1051519 | — |
| 反応物 | 4-(Trifluoromethyl)cyclohexanone | HCID 2777491 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | 3-(4-Trifluoromethyl-cyclohex-1-enyl)-pyridin-2-ylamine | HCID 67341450 | 26% |
反応手順
Prepared in analogy to example 262 step a-b), starting from N-(pyridin-2-yl)pivalamide and 4-(trifluoromethyl)cyclohexanone. 3-(4-Trifluoromethyl-cyclohex-1-enyl)-pyridin-2-ylamine was obtained after column chromatography on silica gel using a gradient from CH2Cl2 to CH2Cl2/MeOH 19:1 (v/v) as eluent as a white solid (yield: 26% over 2 steps).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08486967B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-38af24023a4e4d978a1f4dac4a21afb5 |
| 出典メモ | uspto-grants-2013_07 |