1-(4-T-Butylphenyl)-3-chloropropan-1-one → 5-Tert-butyl-2,3-dihydroinden-1-one

HRID 451587

反応式

HRID 451587 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:15])[CH2:12][CH2:13]Cl)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>S(=O)(=O)(O)O>[C:1]([C:5]1[CH:10]=[C:9]2[C:8](=[CH:7][CH:6]=1)[C:11](=[O:15])[CH2:12][CH2:13]2)([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 1

HCID 222283931-(4-T-Butylphenyl)-3-chloropropan-1-one

生成物 1

HCID 110305765-Tert-butyl-2,3-dihydroinden-1-one

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
95 °C

実験手順

1-(4-tert-Butylphenyl)-3-chloro-1-propanone (22.25 g, 99 mmol) was dissolved in concentrated sulfuric acid (100 ml) and heated on a water bath at 95° C. for 2.5 hours. The reaction mixture was cooled, poured onto ice, and extracted with diethyl ether. The combined organic extracts were washed with saturated aqueous sodium bicarbonate, dried with magnesium sulfate, and the filtrate was evaporated under reduced pressure to provide the title compound which was used without further purification in the next step.

後処理

  1. temperatureThe reaction mixture was cooled
  2. additionpoured onto ice
  3. extractionextracted with diethyl ether
  4. washThe combined organic extracts were washed with saturated aqueous sodium bicarbonate
  5. dry with materialdried with magnesium sulfate
  6. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-04a17c82613e47bba8fff76f66057048
出典データセット
uspto-grants-2013_07
特許番号
US08487116B2

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