Hydrochloric Acid → HCID 86596673、化合物

HRID 451617

反応式

HRID 451617 の反応式
[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[CH2:9][CH2:8]2)([CH3:4])([CH3:3])[CH3:2].[N:15](OCCC(C)C)=[O:16].Cl>CO>[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[C:9](=[N:15][OH:16])[CH2:8]2)([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 110305765-Tert-butyl-2,3-dihydroinden-1-one

生成物 1

HCID 86596673HCID 86596673、化合物収率 137.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-tert-butyl-indan-1-one (9.39 g, 39 mmol) was dissolved in 150 ml methanol. Isoamyl nitrite (5 g, 43 mmol) and conc. HCl (5 ml) were added, and the reaction stirred at ambient temperature for 44 hours. The solvents were removed under vacuum to give 11.67 grams of crude product which was used without further purification. 1H NMR (300 MHz, CDCl3) 7.82 (d, 1H), 7.51 (s, 1H), 7.49 (d, 1H), 3.83 (s, 2H), 3.50 (s, 1H, OH) 1.34 (s, 9H). MS (CSI) m/e 218 (M+H)+, 235 (m+NH4)+

後処理

  1. customThe solvents were removed under vacuum

出典と根拠

ORDレコード
ord-33f1e9d4c2fa409d9d3d76d67b539f6d
出典データセット
uspto-grants-2013_07
特許番号
US08487116B2

関連ノート

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