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Triacetoxyperiodinane → 1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triacetoxyperiodinane | HCID 159087 | — |
| 反応物 | 1-Tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | HCID 5148299 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate | HCID 4251853 | — |
反応手順
To a solution of 4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (5 g, 20.4 mmol) in DCM (100 mL), Dess-Martin periodinane (12.97 g, 30.6 mmol) is added. After completion of the reaction as judged by TLC the reaction is quenched with sat NaHCO3, washed with sat sodium thiosulfate and extracted with DCM. The organics are dried and evaporated and used crude in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541432B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-7e231e86ac7d47e0a5156a0df52cfadb |
| 出典メモ | uspto-grants-2013_09 |