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(R)-tert-butyl 3-((R)-(2-(tert-butyldimethylsilyloxy)ethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate → 2-((R)-(3-chlorophenyl)((R)-piperidin-3-yl)methoxy)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (R)-tert-butyl 3-((R)-(2-(tert-butyldimethylsilyloxy)ethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate | HCID 59201708 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-((R)-(3-chlorophenyl)((R)-piperidin-3-yl)methoxy)ethanol | HCID 59201741 | — |
反応手順
A solution of crude (R)-tert-butyl 3-((R)-(2-(tert-butyldimethylsilyloxy)ethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate in CH3CN (100 mL) and 2 N aq HCl (100 mL) was vigorously stirred at rt for 2 d. The solvents were removed in vacuo to give the HCl salt of 2-((R)-(3-chlorophenyl)((R)-piperidin-3-yl)methoxy)ethanol, which was used in the next step without further purification. LC-MS (3 min) tR=1.05 min m/z 272, 270 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08487108B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-5b404a4e2a6445a599aa7c2199b939f4 |
| 出典メモ | uspto-grants-2013_07 |