2-Phthalimidoacetaldehyde Diethyl Acetal → Phthalylglycine aldehyde

HRID 451752

反応式

HRID 451752 の反応式
C([O:3][CH:4](OCC)[CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16])C>C(O)=O>[O:16]=[C:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:14](=[O:15])[N:6]1[CH2:5][CH:4]=[O:3]

参加物

3

反応物 1

HCID 3152862-Phthalimidoacetaldehyde Diethyl Acetal

生成物 1

HCID 76201Phthalylglycine aldehyde収率 95.2%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

2-(2,2-diethoxyethyl)isoindoline-1,3-dione (40.00 g, 0.15 mol) was dissolved in 85% formic acid (150 mL) and the mixture was stirred for 2 h at rt. After tlc analysis indicated full conversion to the aldehyde (2,4-DNP stain used for visualization), the solvent was removed and the resultant solid was dried at 150 mm torr vacuum to give 2-(1,3-dioxoisoindolin-2-yl)acetaldehyde (27 g, 95%).

後処理

  1. customthe solvent was removed
  2. customthe resultant solid was dried at 150 mm

出典と根拠

ORDレコード
ord-7c6a2973a05a448b902877617bb39bcf
出典データセット
uspto-grants-2013_07
特許番号
US08487108B2

関連ノート

読み込み中…