化工社化工社 化学情報印刷レポート · 研究参考用
Tetrahydrofuran → 3-Cyclohexylpropyl-(ethyl)carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 2,5-Dioxopyrrolidin-1-yl 2-(trimethylsilyl)ethyl carbonate | HCID 5018386 | — |
| 反応物 | (S)-tert-butyl 1-cyclohexyl-3-(ethylamino)propan-2-ylcarbamate | HCID 59201304 | — |
| 生成物 | 3-Cyclohexylpropyl-(ethyl)carbamate | HCID 131730716 | 45% |
反応手順
To a solution of (S)-tert-butyl 1-cyclohexyl-3-(ethylamino)propan-2-ylcarbamate (338 mg) and TeocOSu (386 mg, 1.49 mmol) in THF was added TEA (0.6 mL). The resulting solution was stirred at rt for 30 min and evaporated. The residue was purified through chromatography on silica gel to give (S)-2-(trimethylsilyl)ethyl 2-(N-tert-butoxycarbonyl)amino)-3-cyclohexylpropyl-(ethyl)carbamate (287 mg, 45% over 2 steps).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08487108B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-e0de30f8a9114fa4950dea2fb477176d |
| 出典メモ | uspto-grants-2013_07 |