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Ammonium Chloride → (S)-tert-butyl 1-cyclohexyl-3-hydroxypentan-2-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | (S)-tert-butyl 1-cyclohexyl-3-oxopentan-2-ylcarbamate | HCID 15730499 | — |
| 溶媒 | MeOH tetrahydrofuran | HCID 21899815 | — |
| 生成物 | (S)-tert-butyl 1-cyclohexyl-3-hydroxypentan-2-ylcarbamate | HCID 59201568 | — |
反応手順
To a solution of (S)-tert-butyl 1-cyclohexyl-3-oxopentan-2-ylcarbamate in THF/MeOH (604/15 mL) at 0° C. was carefully added NaBH4 (630 mg, 16.66 mmol). After 20 min, sat. aq. NH4Cl was added to quench the reaction, and extracted with EtOAc, washed with brine, dried over Na2SO4, filtered, and concentrated to give (S)-tert-butyl 1-cyclohexyl-3-hydroxypentan-2-ylcarbamate (4.77 g, 96%, in a ratio of 40:60) as a white solid. MS ESI +ve m/z 286 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08487108B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-0db4cce6a1e04c7090574e707c3d1e2a |
| 出典メモ | uspto-grants-2013_07 |