関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tributylstannane | HCID 5948 | — |
| 反応物 | Azobisisobutyronitrile | HCID 6547 | — |
| 反応物 | Z-Dehydro-Ala-OMe | HCID 3525700 | — |
| 反応物 | 1-Bromo-1-methylcyclohexane | HCID 12502129 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | Methyl 2-(benzyloxycarbonylamino)-3-(1-methylcyclohexyl)propanoate | HCID 59201682 | — |
反応手順
A mixture of 1-bromo-1-methylcyclohexane (7.200 g, 3.0 equiv), tributyltin hydride (8 mL, 2.2 equiv), methyl 2-(benzyloxycarbonylamino)acrylate (3.120 g, 13.26 mmol, 1.0 equiv), and 2,2′-azobisisobutyronitrile (0.370 g, 0.17 equiv) in benzene (30 mL) was heated at 100° C. for 6 h. After the reaction mixture was evaporated under reduced pressure, the crude methyl 2-(benzyloxycarbonylamino)-3-(1-methylcyclohexyl)propanoate was used directly in the next step without further purification. MS ESI +ve m/z 356 (M+Na).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08487108B2 |
|---|
| 出典データセット | uspto-grants-2013_07 |
|---|
| ORD ID | ord-6236388c73a9446e86fe57190f3c8112 |
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| 出典メモ | uspto-grants-2013_07 |
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