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Methanol → Tyrosine Methyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | L-Tyrosine | HCID 6057 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 生成物 | Tyrosine Methyl Ester | HCID 70652 | 100% |
反応手順
To a solution of L-tyrosine (45.3 g, 0.25 mol) in CH3OH (680 mL), SOCl2 (44.6 g, 0.375 mol) was added dropwise at 0° C. After addition, the mixture was allowed to warm to rt and then refluxed for overnight. The reaction mixture was concentrated to give L-tyrosine methyl ester (49.2 g, 100%), which was used in the next step without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08487108B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-81cf74bb249a4b16970c0fb28ecabe21 |
| 出典メモ | uspto-grants-2013_07 |