HCID 58017434、化合物 → 2-Amino-3-(oxan-3-yl)propan-1-ol
反応式
[NH:1]([C@@H:3]([CH2:6][CH:7]1[CH2:12][CH2:11][CH2:10][O:9][CH2:8]1)[CH2:4][OH:5])N>CO.[Ni]>[NH2:1][C@@H:3]([CH2:6][CH:7]1[CH2:12][CH2:11][CH2:10][O:9][CH2:8]1)[CH2:4][OH:5]参加物
4
実験手順
To the solution of (2S)-2-hydrazinyl-3-(tetrahydro-2H-pyran-3-yl)propan-1-ol (5.79 g, 0.033 mol) in MeOH (100 mL) was added Raney Ni. The flask was degassed and equipped with a hydrogen inflated balloon. The flask was dipped into an ultrasound bath filled with water and sonicated for 4 hr at rt until the starting material was completely consumed. The mixture was then filtered through celite, and the filter cake was washed with MeOH (2×30 mL). Removal under reduced pressure gave (2S)-2-amino-3-(tetrahydro-2H-pyran-3-yl)propan-1-ol (5.4 g, 90%).
後処理
- customThe flask was degassed
- customequipped with a hydrogen inflated balloon
- customThe flask was dipped into an ultrasound bath
- additionfilled with water
- customsonicated for 4 hr at rt until the starting material
- customwas completely consumed
- filtrationThe mixture was then filtered through celite
- washthe filter cake was washed with MeOH (2×30 mL)
- customRemoval under reduced pressure
出典と根拠
- ORDレコード
- ord-c4c015bc6501412cb877396c4ede027d
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08487108B2
反応ノート
読み込み中…