化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → (R)-3-(1H-benzo[d]imidazol-6-yl)-4-phenyloxazolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,2-Diaminocyclohexane | HCID 4610 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Bromobenzene-1,2-diamine | HCID 323593 | — |
| 反応物 | (4R)-4-phenyl-1,3-oxazolidin-2-one | HCID 730425 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 溶媒 | Formic Acid | HCID 284 | — |
| 生成物 | (R)-3-(1H-benzo[d]imidazol-6-yl)-4-phenyloxazolidin-2-one | HCID 58229172 | — |
反応手順
The compound was synthesized starting from (R)-4-phenyloxazolidin-2-one (1 equiv., 0.163 g, 1 mmol), 4-bromobenzene-1,2-diamine (1 equiv., 0.187 g, 1 mmol), copper(I) iodide (0.1 equiv., 0.019 g, 0.1 mmol), potassium carbonate (2 equiv., 0.276 g, 2 mmol), cyclohexane-1,2-diamine (0.1 equiv., 0.012 mL, 0.1 mmol), 5N HCl (3.4 mL), formic acid (0.343 mL) as described in method 5 step D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08486940B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-982164221e9645828fc8576559b0bf5c |
| 出典メモ | uspto-grants-2013_07 |