Ethyl orthoformate → HCID 67210516、化合物
反応式
[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:29]=[CH:28][C:13]3/[C:14](=[CH:23]/[C:24]([NH:26][NH2:27])=[O:25])/[C:15]4[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=4[CH2:17][CH2:18][C:12]=3[CH:11]=2)[C:7]2[CH:30]=[CH:31][CH:32]=[CH:33][C:6]=2[N:5]=1)[CH2:2][CH3:3].[CH:34](OCC)(OCC)OCC>>[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:29]=[CH:28][C:13]3/[C:14](=[CH:23]/[C:24]4[O:25][CH:34]=[N:27][N:26]=4)/[C:15]4[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=4[CH2:17][CH2:18][C:12]=3[CH:11]=2)[C:7]2[CH:30]=[CH:31][CH:32]=[CH:33][C:6]=2[N:5]=1)[CH2:2][CH3:3]参加物
3
反応条件
- 温度
- 120 °C
実験手順
To (E)-[2-(2-propylbenzimidazol-1-yl)methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene]acetohydrazide (27 mg, 0.062 mmol) obtained in Example 7, step 1 was added triethyl orthoformate (0.5 mL), and the mixture was stirred at 120° C. for 20 hr. The mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=70/30 to 0/100) to give the title compound (compound 11) (26 mg, 93%).
後処理
- concentrationThe mixture was concentrated under reduced pressure