Water → 2-(methoxymethyl)-1H-benzimidazole

HRID 452189ノート

反応式

HRID 452189 の反応式
Cl[CH2:2][C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[CH3:12][OH:13].C[O-].[Na+].O>CO>[CH3:12][O:13][CH2:2][C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 785712-ChloromethylbenzimidazoleHCID 23694274Sodium methanolate methanol

生成物 1

HCID 2429502-(methoxymethyl)-1H-benzimidazole収率 19%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-Chloromethylbenzimidazole (1.67 g, 10 mmol) was suspended in methanol (34 mL), 28% sodium methoxide methanol solution (9.6 mL, 50 mmol) and water (50 mL) were added, and the mixture was stirred at room temperature for 20 min. The precipitated solid was collected by filtration, and purified by silica gel column chromatography (chloroform/methanol=100/0 to 93/7) to give the title compound (303 mg, 19%).

後処理

  1. filtrationThe precipitated solid was collected by filtration
  2. custompurified by silica gel column chromatography (chloroform/methanol=100/0 to 93/7)

出典と根拠

ORDレコード
ord-531e5954d5dc4528ad35a8dfe02b238b
出典データセット
uspto-grants-2013_07
特許番号
US08486980B2

反応ノート

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