関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Hydroxybenzyl alcohol | HCID 102 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 2-Bromoethyl methyl ether | HCID 80972 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | [3-(2-Methoxyethoxy)phenyl]methanol | HCID 20110194 | — |
反応手順
A mixture of 10 g (80.6 mmol) of 3-(hydroxymethyl)phenol, 78.4 g (241.7 mmol) of Cs2CO3 and 8.4 mL (88.6 mmol) of bromoethyl methyl ether in 150 mL of CH3CN is heated for 12 hours at 110° C. After cooling to room temperature, the medium is filtered, concentrated under reduced pressure, taken up in 500 mL of DCM, washed with brine (2×100 mL) dried over Na2SO4, filtered and then concentrated under reduced pressure. 10.9 g of 3-(2-methoxyethoxy)phenyl]methanol are obtained in the form of a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08541455B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-508484e1afec43eb83cbb806dec4e237 |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
