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Water → 4-Bromo-2-methyl-N-(2,2,2-trifluoro-ethyl)-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Ethanamine, 2,2,2-trifluoro- | HCID 9773 | — |
| 反応物 | 4-Bromo-2-methylbenzoic acid | HCID 99570 | — |
| 反応物 | 1-(3-Diethylaminopropyl)-3-ethylcarbodiimide hydrochloride | HCID 9964512 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Bromo-2-methyl-N-(2,2,2-trifluoro-ethyl)-benzamide | HCID 66784310 | 58.1% |
反応手順
In a solution of 5.00 g of 4-bromo-2-methyl benzoic acid and 3.45 g of 2,2,2-trifluoroethylamine in 30 ml of N,N-dimethylformamide, 5.79 g of 1-[3-(diethylamino)propyl]-3-ethylcarbodiimide hydrochloride was added with stirring at room temperature, and stirred at the same temperature for 1.5 hour. After the completion of the reaction, 80 ml of water was added, and precipitated crystal was filtered off, washed with water and dried to obtain 4.00 g of the aimed product as white crystal.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08492311B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-ce9d8834890c497b84e596722dc2eec6 |
| 出典メモ | uspto-grants-2013_07 |