1,1,1-Trimethoxy-2-chloroethane → 2-(Chloromethyl)-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole

HRID 452600

反応式

HRID 452600 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([NH:12][NH2:13])=[O:11])=[CH:9][C:4]=2[CH2:3][CH2:2]1.[Cl:14][CH2:15][C:16](OC)(OC)OC>>[Cl:14][CH2:15][C:16]1[O:11][C:10]([C:8]2[CH:7]=[CH:6][C:5]3[O:1][CH2:2][CH2:3][C:4]=3[CH:9]=2)=[N:12][N:13]=1

参加物

3

反応物 2

HCID 1447021,1,1-Trimethoxy-2-chloroethaneHCID 185264692,3-Dihydro-1-benzofuran-5-carbohydrazide

生成物 1

HCID 621997482-(Chloromethyl)-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole収率 75.2%

実験手順

A mixture of 2,3-dihydro-1-benzofuran-5-carbohydrazide (2.02 g, 11.3 mmol) and 2-chloro-1,1,1-trimethoxyethane (7.92 ml, 56.7 mmol) was tightly sealed in a vial, and microwave was irradiated thereon at 160° C. for 5 min. The reaction mixture was recrystallized from hexane to give the title compound (2.01 g, yield 75%) as colorless crystals.

後処理

  1. customwas tightly sealed in a vial, and microwave
  2. customwas irradiated
  3. customThe reaction mixture was recrystallized from hexane

出典と根拠

ORDレコード
ord-fcbba1bdead0480bbce4fdd8f8373a1a
出典データセット
uspto-grants-2013_07
特許番号
US08492378B2

関連ノート

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