Methyl 3-bromo-1-benzofuran-5-carboxylate → Methyl 3-[3-chloro-4-(methylthio)phenyl]-1-benzofuran-5-carboxylate

反応式

Br[C:2]1[C:6]2[CH:7]=[C:8]([C:11]([O:13][CH3:14])=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH:3]=1.[Cl:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][C:21]=1[S:22][CH3:23]>>[Cl:15][C:16]1[CH:17]=[C:18]([C:2]2[C:6]3[CH:7]=[C:8]([C:11]([O:13][CH3:14])=[O:12])[CH:9]=[CH:10][C:5]=3[O:4][CH:3]=2)[CH:19]=[CH:20][C:21]=1[S:22][CH3:23]

参加物

反応物 2

HCID 22481688Methyl 3-bromo-1-benzofuran-5-carboxylate

HCID 686641083-Chloro-4-(methylthio)phenylboronic acid

生成物 1

HCID 68664546Methyl 3-[3-chloro-4-(methylthio)phenyl]-1-benzofuran-5-carboxylate収率 84%

実験手順

In the same manner as in Reference Example 19 and using methyl 3-bromo-1-benzofuran-5-carboxylate instead of methyl 3-iodoimidazo[1,2-a]pyridine-6-carboxylate and [3-chloro-4-(methylthio)phenyl]boronic acid instead of (4-methoxyphenyl)boronic acid, the title compound (yield 84%) was obtained as colorless crystals.

出典と根拠

ORDレコード: ord-99d7adfc29684dd58035a7aa3dc07f02
出典データセット: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08492378B2

反応ノート

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