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Acetoxyacetyl chloride → 2-Oxo-2-[2-[[3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]carbonyl]hydrazino]ethyl acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetoxyacetyl chloride | HCID 26297 | — |
| 反応物 | 3-[3-(Trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide | HCID 68664388 | — |
| 生成物 | 2-Oxo-2-[2-[[3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]carbonyl]hydrazino]ethyl acetate | HCID 68663979 | 94% |
反応手順
In the same manner as in Reference Example 61 and using 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide instead of ethyl 2-aminoisonicotinate and acetoxyacetyl chloride instead of 3-phenylpropanoyl chloride, the title compound (yield 94%) was obtained as colorless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08492378B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-b8ee4722838a4af8a11e55105d686a9e |
| 出典メモ | uspto-grants-2013_07 |