3-(3-Trifluoromethylphenyl)propanoic acid → 6-[5-[2-[3-(Trifluoromethyl)phenyl]ethyl]-1,3,4-oxadiazol-2-yl]imidazo[1,2-a]pyridine
反応式
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([C:10]([NH:12][NH2:13])=[O:11])[CH:7]=[CH:6][C:5]=12.[F:14][C:15]([F:28])([F:27])[C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][C:24](O)=O)[CH:19]=[CH:20][CH:21]=1>>[F:14][C:15]([F:27])([F:28])[C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][C:24]2[O:11][C:10]([C:8]3[CH:7]=[CH:6][C:5]4[N:4]([CH:3]=[CH:2][N:1]=4)[CH:9]=3)=[N:12][N:13]=2)[CH:19]=[CH:20][CH:21]=1参加物
3
実験手順
In the same manner as in Example 14 and using imidazo[1,2-a]pyridine-6-carbohydrazide instead of 1H-benzotriazole-5-carbohydrazide and 3-[3-(trifluoromethyl)phenyl]propionic acid instead of 3-(3-cyanophenyl)propionic acid, the title compound (yield 58%) was obtained as colorless crystals.
出典と根拠
- ORDレコード
- ord-644672c8394c4d6ea1f5716525d9293e
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08492378B2
反応ノート
読み込み中…