Benzonitrile, 3-(bromomethyl)- → 3-[[[5-[3-[4-(Methylsulfinyl)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazol-2-yl]thio]methyl]benzonitrile

HRID 452781

反応式

HRID 452781 の反応式
[CH3:1][S:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:14]3[CH:15]=[C:16]([C:19]4[O:23][C:22]([SH:24])=[N:21][N:20]=4)[CH:17]=[CH:18][C:13]=3[O:12][CH:11]=2)=[CH:6][CH:5]=1)=[O:3].Br[CH2:26][C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[C:30]#[N:31]>>[CH3:1][S:2]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[C:14]3[CH:15]=[C:16]([C:19]4[O:23][C:22]([S:24][CH2:26][C:27]5[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=5)[C:30]#[N:31])=[N:21][N:20]=4)[CH:17]=[CH:18][C:13]=3[O:12][CH:11]=2)=[CH:8][CH:9]=1)=[O:3]

参加物

3

反応物 2

HCID 97249Benzonitrile, 3-(bromomethyl)-HCID 178504596HCID 178504596、化合物

生成物 1

HCID 686642773-[[[5-[3-[4-(Methylsulfinyl)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazol-2-yl]thio]methyl]benzonitrile収率 76%

実験手順

In the same manner as in Example 7 and using 5-[3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazole-2-thiol instead of 5-(1H-indazol-5-yl)-1,3,4-oxadiazole-2-thiol and 3-(bromomethyl)benzonitrile instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 76%) was obtained as colorless crystals.

出典と根拠

ORDレコード
ord-bea6f6dadf0044a99d3fab003b50561d
出典データセット
uspto-grants-2013_07
特許番号
US08492378B2

関連ノート

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