化工社化工社 化学情報印刷レポート · 研究参考用
Acetone → HCID 178476642、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Metformin Hydrochloride | HCID 14219 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | HCID 178476642 | HCID 178476642 | 92.4% |
反応手順
0.4 L of water, 241.50 g of sodium hydroxide, 9 L of acetone and 1 Kg of metformin hydrochloride were added to a 20 L reactor, and stirred for 2 hours and 40 minutes at room temperature. The resulting crystal was filtered and washed with acetone. 0.2 L of water and 1 L of acetic acid were added and stirred. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 1,056 g of metformin acetate (yield: 92.4%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541474B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-050d89d8ac0a418c87d5623f7c8d671e |
| 出典メモ | uspto-grants-2013_09 |