Acetic Acid → HCID 178476642、化合物

HRID 45304

反応式

HRID 45304 の反応式
[C:1]([OH:4])(=[O:3])[CH3:2].[CH3:5][N:6]([C:8]([NH:10][C:11]([NH2:13])=[NH:12])=[NH:9])[CH3:7]>CC(C)=O>[CH3:5][N:6]([C:8]([NH:10][C:11]([NH2:13])=[NH:12])=[NH:9])[CH3:7].[C:1]([O-:4])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 178484382HCID 178484382、化合物

生成物 1

HCID 178476642HCID 178476642、化合物収率 59.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

20.00 g (1 equivalent) of metformin hydrochloride and 4.84 g (1 equivalent) of sodium hydroxide were stirred in 200 Ml of ethanol for 2 hours at room temperature, and then remaining solid was filtered and the filtrate was concentrated under reduced pressure. Then 300 Ml of acetone was added to the resulting solid and stirred. Insoluble material was filtered, and the filtrate was concentrated under reduced pressure to obtain 12.0 g of metformin free base. 500 Ml of acetone and 10 Ml (1.45 equivalents) of glacial acetic acid were added to the metformin free base, and then the mixture was stirred. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 13.6 g of metformin acetate (yield: 59.5%).

後処理

  1. filtrationThe resulting crystal was filtered
  2. washwashed with acetone
  3. customdried at 60° C.

出典と根拠

ORDレコード
ord-093ce2a18d824f30afe9cc2c2caeab94
出典データセット
uspto-grants-2013_09
特許番号
US08541474B2

関連ノート

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