化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Metformin Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | HCID 178484382 | HCID 178484382 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Metformin Hydrochloride | HCID 14219 | 76.4% |
反応手順
500 mg of metformin free base was dissolved in 30 Ml of acetone, and then 280 Ml of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then dried with heated air at 70° C. to obtain 490 mg of metformin hydrochloride (yield: 76.4%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541474B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-bb7f28c0f0144c43ad84ff9519be4688 |
| 出典メモ | uspto-grants-2013_09 |