5-Hydroxyindole → 1H-Indole, 5-[[6-[(phenylmethoxy)methyl]-4-pyrimidinyl]oxy]-

関与物質

役割	名称	HCID	仕込み量
反応物	5-Hydroxyindole	HCID 16054	—
反応物	1,8-Diazabicyclo(5.4.0)undec-7-ene	HCID 81184	—
反応物	4-((Benzyloxy)methyl)-6-chloropyrimidine	HCID 53421259	—
溶媒	Acetonitrile	HCID 6342	—
生成物	1H-Indole, 5-[[6-[(phenylmethoxy)methyl]-4-pyrimidinyl]oxy]-	HCID 59394260	—

反応手順

To a solution of 5-hydroxy indole (1.33 g, 10 mmol) and 4-benzyloxymethyl-6-chloro-pyrimidine (2.35 g, 10 mmol) in acetonitrile (20 mL) is added DBU. After 16 h at rt the solution is concentrated under reduced pressure. The residue is purified by FCC (EtOAc/Heptane from 0% to 40%) to give 5-(6-benzyloxymethyl-pyrimidin-4-yloxy)-1H-indole. MS (ESI) m/z 447.0 (M+1).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08492393B2
出典データセット	uspto-grants-2013_07
ORD ID	ord-7cb274b658ab4bdb816a8f488bb21c0a
出典メモ	uspto-grants-2013_07