化工社化工社 化学情報印刷レポート · 研究参考用
Pivaloyl chloride → 2-(2,2-Dimethylpropionylamino)-4-methylthiazole-5-carboxylic Acid Benzylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pivaloyl chloride | HCID 62493 | — |
| 反応物 | N-Benzyl-2-imino-4-methyl-2,3-dihydro-1,3-thiazole-5-carboximidic acid | HCID 210824 | — |
| 生成物 | 2-(2,2-Dimethylpropionylamino)-4-methylthiazole-5-carboxylic Acid Benzylamide | HCID 59369706 | 23% |
反応手順
Following the procedure as described in Example 2, making variations only as required to use 2,2-dimethylpropionyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 23% yield; 1H NMR (CDCl3, 300 MHz) δ 8.85 (s, br, 1H), 7.36-7.25 (m, 5H), 5.91 (s, br, 1H), 4.56 (d, J=5.8 Hz, 2H), 2.60 (s, 3H), 1.27 (s, 9H); MS (ES+) m/z 332.0 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541457B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-9c5547534c57484f8d3031cb2a12717e |
| 出典メモ | uspto-grants-2013_09 |