化工社化工社 化学情報印刷レポート · 研究参考用
Cyclobutanecarbonyl chloride → 2-(Cyclobutanecarbonylamino)-4-methylthiazole-5-carboxylic acid benzylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclobutanecarbonyl chloride | HCID 78705 | — |
| 反応物 | N-Benzyl-2-imino-4-methyl-2,3-dihydro-1,3-thiazole-5-carboximidic acid | HCID 210824 | — |
| 生成物 | 2-(Cyclobutanecarbonylamino)-4-methylthiazole-5-carboxylic acid benzylamide | HCID 59369692 | 46% |
反応手順
Following the procedure as described in Example 2, making variations only as required to use cyclobutanecarbonyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 46% yield; 1H NMR (DMSO-ds, 300 MHz) δ 7.38-7.25 (m, 4H), 5.96 (s, br, 1H), 4.58-4.50 (m, 2H), 3.25-3.14 (m, 1H), 2.53 (s, 3H), 2.42-1.90 (m, 6H); MS (ES+) m/z 330.0 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541457B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-b7ab29657b9a43879daad28b645ddbb0 |
| 出典メモ | uspto-grants-2013_09 |