化工社化工社 化学情報印刷レポート · 研究参考用
HRID 453362作成日：2026年10月26日
3-(Trifluoromethyl)phenyl isocyanate → 1-(4-Methyl-3-(pyrimidin-5-ylcarbamoyl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
https://huagongshe.com/reaction/453362
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-(Trifluoromethyl)phenyl isocyanate | HCID 9483 | — |
| 反応物 | 5-amino-2-methyl-N-(pyrimidin-5-yl)benzamide | HCID 24824047 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 1-(4-Methyl-3-(pyrimidin-5-ylcarbamoyl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea | HCID 16118465 | — |
反応手順
To a suspension of 5-amino-2-methyl-N-(pyrimidin-5-yl)benzamide 26 (0.068 g, 0.30 mmol) in benzene (5 mL) was added 1-isocyanato-3-(trifluoromethyl)benzene (0.046 mL, 0.33 mmol). The reaction was heated at 75° C. for 2 hours, producing a solid precipitate. The mixture was concentrated and chromatographed on silica gel with 94/6 CH2Cl2/MeOH to afford 1-(4-methyl-3-(pyrimidin-5-ylcarbamoyl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea 27 as a white solid. MS m/z: found 416 [MH+], calc. for C20H16F3N5O2=415.13.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08492404B2 |
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| 出典データセット | uspto-grants-2013_07 |
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| ORD ID | ord-9073762e3b754419b86f9e013228e418 |
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| 出典メモ | uspto-grants-2013_07 |
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