N-Benzyl-2-imino-4-methyl-2,3-dihydro-1,3-thiazole-5-carboximidic acid → 4-Methyl-2-(2-trifluoromethoxybenzoylamino)thiazole-5-carboxylic Acid Benzylamide
反応式
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6](Cl)=[O:7].[CH2:15]([NH:22][C:23]([C:25]1[S:29][C:28]([NH2:30])=[N:27][C:26]=1[CH3:31])=[O:24])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([NH:22][C:23]([C:25]1[S:29][C:28]([NH:30][C:6](=[O:7])[C:5]2[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=2[O:3][C:2]([F:14])([F:13])[F:1])=[N:27][C:26]=1[CH3:31])=[O:24])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1参加物
3
実験手順
Following the procedure as described in Example 2, making variations only as required to use 2-trifluoromethoxybenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 30% yield; m.p. 140-141° C.; 1H NMR (CDCl3, 300 MHz) δ 7.98 (dd, J=1.8, 7.8 Hz, 1H), 7.60 (ddd, J=1.8, 7.6, 8.2 Hz, 1H), 7.43 (dt, J=1.0, 7.6 Hz, 1H), 7.46-7.25 (m, 6H), 5.98 (t, J=5.3 Hz, 1H), 4.57 (d, J=5.6 Hz, 2H), 3.1 (s, 3H); MS (ES+) m/z 436 (M+1).
出典と根拠
- ORDレコード
- ord-9c507c6738dc46ae960b0fda44ed1ddf
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541457B2
反応ノート
読み込み中…