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HRID 453519作成日：2026年10月26日
Benzyltrimethylammonium hydroxide → (Z)-N-(4-chlorophenethyl)-4-(2-bromo-4-(2-(methylsulfinyl)-2-(methylthio)vinyl)phenoxy)benzamide
https://huagongshe.com/reaction/453519
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzyltrimethylammonium hydroxide | HCID 66854 | — |
| 反応物 | Methyl (methylsulfinyl)methyl sulfide | HCID 99129 | — |
| 反応物 | N-(4-chlorophenethyl)-4-(2-bromo-4-formylphenoxy)benzamide | HCID 86643286 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (Z)-N-(4-chlorophenethyl)-4-(2-bromo-4-(2-(methylsulfinyl)-2-(methylthio)vinyl)phenoxy)benzamide | HCID 86643287 | 96.1% |
反応手順
N-(4-chlorophenethyl)-4-(2-bromo-4-formylphenoxy)benzamide (1.6 g, 3.5 mmol) was diluted with THF (10 mL) followed by the addition of N,N,N-trimethyl(phenyl)methanaminium hydroxide (0.79 ml, 1.7 mmol) and methylsulfinyl (methylthio)methane (0.87 g, 7.0 mmol). The reaction was stirred at 70° C. for 2 hours. The reaction mixture was loaded directly onto a silica gel column and eluted with DCM:MeOH (98:2) to yield (Z)—N-(4-chlorophenethyl)-4-(2-bromo-4-(2-(methylsulfinyl)-2-(methylthio) vinyl)phenoxy)benzamide (1.9 g, 96% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08492437B2 |
|---|
| 出典データセット | uspto-grants-2013_07 |
|---|
| ORD ID | ord-558783616cce47f3bf0a9cc5418151ff |
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| 出典メモ | uspto-grants-2013_07 |
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