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Benzoyl chloride, 3,4-dichloro- → 2-(3,4-Dichlorobenzoylamino)-4-methylthiazole-5-carboxylic Acid Benzylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl chloride, 3,4-dichloro- | HCID 76403 | — |
| 反応物 | N-Benzyl-2-imino-4-methyl-2,3-dihydro-1,3-thiazole-5-carboximidic acid | HCID 210824 | — |
| 生成物 | 2-(3,4-Dichlorobenzoylamino)-4-methylthiazole-5-carboxylic Acid Benzylamide | HCID 59369672 | 15% |
反応手順
Following the procedure as described in Example 2, making variations only as required to use 3,4-dichlorobenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 15% yield; m.p. 212-214° C.; 1H NMR (CD3OD, 300 MHz) δ 8.21 (d, J=2.0 Hz, 1H), 7.93 (dd, J=2.0, 8.4 Hz, 1H), 7.68 (d, J=8.4 Hz, 1H), 7.33-7.23 (m, 5H), 4.50 (s, 2H), 2.54 (s, 3H); MS (ES+) m/z 420.0 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541457B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-0247335befb84638afee45c80231f782 |
| 出典メモ | uspto-grants-2013_09 |