Acetyl chloride → N,N-dimethyl-4-phenylpiperidin-4-amine dihydrochloride

HRID 453881ノート

反応式

HRID 453881 の反応式
C([Cl:4])(=O)C.C(OC([N:12]1[CH2:17][CH2:16][C:15]([N:24]([CH3:26])[CH3:25])([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:14][CH2:13]1)=O)(C)(C)C.CO.C(Cl)(Cl)[Cl:30]>CO>[ClH:4].[ClH:30].[CH3:25][N:24]([CH3:26])[C:15]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:14][CH2:13][NH:12][CH2:17][CH2:16]1

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 21584188Chloroform methanolHCID 57831267tert-Butyloxycarbonyl-4-(dimethylamino)-4-phenylpiperidine

生成物 1

HCID 67366566N,N-dimethyl-4-phenylpiperidin-4-amine dihydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

10 equivalents of acetyl chloride were added to a solution of tert-butyloxycarbonyl-4-(dimethylamino)-4-phenylpiperidine in methanol at 0° C. The reaction course was monitored by thin-layer chromatography (10% MeOH/CHCl3). Once the conversion was complete, the solvent was removed under reduced pressure and the product obtained in the form of a solid.

後処理

  1. customthe solvent was removed under reduced pressure
  2. customthe product obtained in the form of a solid

出典と根拠

ORDレコード
ord-809c0d9282fe4a69a7afb3578ff2a06b
出典データセット
uspto-grants-2013_07
特許番号
US08492559B2

反応ノート

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