2-(7-Cyano-1H-indol-1-yl)acetic acid → 2-(7-(Aminomethyl)-1H-indol-1-yl)acetic acid

HRID 453917ノート

反応式

HRID 453917 の反応式
[C:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[N:10]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=[CH:8]2)#[N:2].[H][H]>CO.[Ni]>[NH2:2][CH2:1][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[N:10]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=[CH:8]2

参加物

5

反応物 2

HCID 594737242-(7-Cyano-1H-indol-1-yl)acetic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 594736972-(7-(Aminomethyl)-1H-indol-1-yl)acetic acid収率 96%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

Raney Ni (7.0 g) was added to a solution of 2-(7-cyano-1H-indol-1-yl)acetic acid (700 mg, 3.5 mmol) in MeOH (15 ml), and the mixture was hydrogenated for 6 h at RT and 60 psi hydrogen in a Parr apparatus. The reaction mixture was filtered over celite and the filtrate was concentrated under vacuum. The crude product so obtained was used directly in the following stage without being purified further. Yield: 96% (692 mg, 3.36 mmol)

後処理

  1. filtrationThe reaction mixture was filtered over celite
  2. concentrationthe filtrate was concentrated under vacuum

出典と根拠

ORDレコード
ord-8fff7e95da214424820948a9ade5d236
出典データセット
uspto-grants-2013_07
特許番号
US08492559B2

反応ノート

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