4-Fluorobenzyl chloride → 5-(4-Fluoro-benzyloxy)-2-nitro-meta-xylene

HRID 453940

反応式

HRID 453940 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([OH:12])[CH:5]=[C:6]([CH3:11])[C:7]=1[N+:8]([O-:10])=[O:9].[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][O:12][C:4]2[CH:5]=[C:6]([CH3:11])[C:7]([N+:8]([O-:10])=[O:9])=[C:2]([CH3:1])[CH:3]=2)=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 96024-Fluorobenzyl chlorideHCID 11430Potassium CarbonateHCID 1384663,5-Dimethyl-4-nitrophenol

生成物 1

HCID 670834645-(4-Fluoro-benzyloxy)-2-nitro-meta-xylene

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 3,5-dimethyl-4-nitrophenol (0.97 g, 5.79 mmol), 4-fluorobenzyl chloride (1.26 g, 8.69 mmol) and anhydrous potassium carbonate (1.24 g, 9.0 mmol) in 50 ml of acetone was stirred under reflux for 22 hours. TLC showed this reaction is complete. The reaction mixture was cooled to room temperature and filtered and washed with acetone. The filtrate was evaporated to dryness to give the crude product, which was used for next step without further purification.

後処理

  1. temperatureunder reflux for 22 hours
  2. filtrationfiltered
  3. washwashed with acetone
  4. customThe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-a6ac003ef0014afa89d6ce38f6a7d273
出典データセット
uspto-grants-2013_07
特許番号
US08492588B2

関連ノート

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